Schistosome E/S products released in the first 3 hours after infection (0-3hRP) [10] stimulate both dendritic cells (DC) and macrophages (M) through binding of constituent ligands to pattern recognition receptors (PRR) such as Toll-like receptors (TLRs) [11], and C-type lectins (CLRs) including the mannose receptor (MR) [12]. Here, NR3C2 is linked to infection.