From observed structures of myosin with various nucleotide analogs [2], [3], [23], it is plausible to assume that the lever arm of myosin in M.ATP and M.ADP.Pi is in the pre-stroke position and the lever arm in other states is in the post-stroke position; therefore, processes 4 and 2 in Eq.1 should correspond to lever-arm stroke during force generation and the recovery stroke, respectively. Here, MYH14 is linked to stroke disorder.