In other words, anxiety and depression may have a statistical interaction with ghrelin such that the effect of ghrelin on body weight is stronger for depressed (or anxious) migraine patients compared to non-depressed (or non-anxious) migraine patients, and depressed (or anxious) migraine patients who also have high levels of ghrelin may be more vulnerable to obesity. This evidence concerns the gene GHRL and depressive symptom measurement.