GHRL and obesity due to melanocortin 4 receptor deficiency: In other words, anxiety and depression may have a statistical interaction with ghrelin such that the effect of ghrelin on body weight is stronger for depressed (or anxious) migraine patients compared to non-depressed (or non-anxious) migraine patients, and depressed (or anxious) migraine patients who also have high levels of ghrelin may be more vulnerable to obesity.