FOS and Alzheimer disease: 2003; Cummings 2006), and in the PVT for its role in attention processing (Allingham et al. 1998; Van der Werf et al. 2002; Heydendael et al. 2013). Again, there was a tendency for AD rats to have more basal Fos than CR in these regions. Although there was no main effect of diet, this higher basal neuronal activation meant stress only significantly activated ARC and PVT neurons in the CR rats (Table 2).