1995). Angiotensin‐converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), which prevent the production or action of Ang II, respectively, are potent antihypertensive agents associated with reduction in cardiovascular disease burden, independent of their BP lowering effect (Lewis et al. 1993; Yusuf et al. 2000; Brenner et al. 2001; Dahlof et al. 2002). This evidence concerns the gene ACE and cardiovascular disorder.