2002). Mice that do not express fibulin‐5 (Fbln5−/−) have loose skin, emphysema, and tortuous arteries with reduced compliance (Nakamura et al. 2002; Yanagisawa et al. 2002). Reduced compliance in Fbln5−/− carotid arteries is detectable as early as 3 weeks of age (Wan and Gleason 2013), but compliance has not been measured at earlier time points. Elastic fiber assembly occurs in late embryonic and early postnatal development and is essentially complete by 3 weeks of age (Wagenseil and Mecham 2009). Here, FBLN5 is linked to pulmonary emphysema.