2009), we find protective effects of chronic GHS‐R deficiency against obesity‐induced hypertension. Thus, while few and only modest GHS‐R antagonist effects on body weight and food intake have been described (Xin et al. 2006; Esler et al. 2007; Rudolph et al. 2007; Puleo et al. 2012), GHS‐R antagonism may provide beneficial cardiovascular effects in obesity. This evidence concerns the gene GHSR and obesity due to melanocortin 4 receptor deficiency.