GHSR and hypertensive disorder: 2005). In future experiments it will be important to explore whether a sexual dimorphism is also apparent in cardiovascular responses to GHS‐R deficiency, as this might have significant implications for potential therapeutic outcomes. Future experiments, using mice with tissue‐/neuronal‐subpopulation‐specific expression of GHS‐R (Zigman et al. 2005) are needed to determine the tissue/CNS site responsible for GHS‐R deficiency's protective effects against the development of hypertension.