After injection through the peripheral venous system, the microbubbles, combined with the modified, focused ultrasound cavitation equipment, can perform targeted irradiation of the tumor(s) of subcutaneous translocation colon cancer in nude mice, and additionally release endostatins to inhibit tumor angiogenesis, on the basis that UMMD has destroyed and blocked tumor microvasculature. Here, COL18A1 is linked to neoplasm.