AKT1 and colonic neoplasm: Since the AKT expression was different in the sorted CD133positive/CD44positiveand CD133negative/CD44negative populations, the influence of AKT isoforms was evaluated using the colon cancer cell-line DLD-1 and the AKT1, AKT2 and AKT1/2 isogenic knock-out cell-lines, see Figure 3AB, and confirmation of knock-outs in Figure S2.