When mice were treated with siRNA RET/PTC3-SQ NPs, tumour growth was strikingly inhibited compared to those receiving siRNA CT-SQ NPs, non-vectorized siRNA RET/PTC3 or saline solution (60% inhibition of tumoral volume compared to saline treated mice, LSD test, p<0.001) (Fig. 6A). Here, NCOA4 is linked to neoplasm.