The oyster transcription factor cAMP response element-binding protein (CREB) [18], the oyster Tolloid-like gene [19] and a tetraspanin family member gene [20] are involved in oyster immune responses against infection, and a novel homolog of human soluble TRAIL (TNF related apoptosis-inducing ligand), oyster sTRAIL, can suppress RLO infection through activation of p38-MAPK pathway [21]. This evidence concerns the gene TNFSF10 and infection.