EGFR and colorectal carcinoma: A randomized clinical trial conducted by the National Cancer Institute of Canada Clinical Trials Group (NCIG CTG) in collaboration with the Australasian Gastro-Intestinal Trials Group (AGITG) showed that, among CRC patients who did not respond to advanced chemotherapy, monotherapy with cetuximab—a monoclonal antibody directed against the epidermal growth factor receptor (EGFR)—improved their overall survival and progression-free survival and preserved their quality of life in comparison to best supportive care alone [161].