In previous finding, orexin-1 receptor, a one of orexin-A receptor, immunoreactivity in the cortex that vulnerable brain region to ischemic stress was increased after cerebral ischemia [61] and i.c.v. orexin-A suppressed the development of infarction through increasing the cerebral blood flow [62]. The gene discussed is HCRT; the disease is Cerebral ischemia.