We also have found that the treatment with dRK6 that inhibits VEGF-A-VEGFR2 binding did not alter hyperglycemia, but resulted in a severe form of renal damage in type 2 db/db mice, regardless of the treatment duration and brought about the suppression of the eNOS-nitric oxide (NO) axis, followed by the uncoupling of VEGF from eNOS-NO [18]. The gene discussed is VEGFA; the disease is Hyperglycemia.