In this study we analyzed the expression of COX-2, miR-101 and miR-16 -both with COX-2 inhibiting effects- and miR-21 -with pro-angiogenic and pro-inflammatory effects- in relation to expression of various angiogenic factors in human HCC in cirrhotic and noncirrhotic liver. Here, PTGS2 is linked to hepatocellular carcinoma.