Wang et al., in their report evaluating traditional and fast track approaches, suggest a significant increase of IL-6 and CRP during the first five PODs in both LC and OC groups, but they found that the values of postoperative CRP and IL-6 in the traditional laparoscopic operation group and fast-track laparoscopic operation group were significantly lower, compared with the open groups [18]. This evidence concerns the gene CRP and laryngotracheoesophageal cleft.