They also demonstrated that MYCN siRNA silencing blocked VEGF secretion in MYCN amplified neuroblastoma cells showing the potential of MYCN as a target for the treatment of highly vascularized malignant neuroblastoma showing a direct relation between MYCN downregulation and VEGF secretion.In this study we demonstrate that PI3K/Akt pathway inhibition caused by sunitinib treatment induces GSK3-β dephosphorylation promoting Mycn degradation in MYCN amplified neuroblastoma cells. This evidence concerns the gene AKT1 and neuroblastoma.