Metavir fibrosis stage inversely correlates with the degranulation activity of IH-NK cells (Figure 4C); this is supported by the observation of 5.7% of IH-NK cells from HCV-infected patients were involved in the degranulation process at F0/1 stage while only 3.4% of CD107a+IH-NK cells were detected at F3/4 stage (p = 0.022). The gene discussed is LAMP1; the disease is isolated hemihyperplasia.