Indeed, our research group recently demonstrated that natural isoprenoids (geraniol, farnesol, geranylgeraniol, menthol and others) are able to rescue the MKD-inflammatory phenotype, by affecting the production of cytokines (IL-1β, IL-18, TNF-α) and inflammatory markers [serum amyloid A (SAA), and apoptosis] both in vitro and in vivo [10]. The gene discussed is TNF; the disease is mevalonic aciduria.