GAN and amyotrophic lateral sclerosis: While NF aggregation has been reported in many neurodegenerative disorders, including Alzheimer’s, Parkinson’s diseases and Amyotrophic Lateral Sclerosis, possibly as a results of neuron injury, the disorganization of all classes of IFs is unique to GAN and supports a crucial role of Gigaxonin in sustaining cytoskeleton architecture [6].