ADRB2 and congestive heart failure: It occurs after a prolonged period of myocardial ischemia, which can result in cardiac electrophysiological disturbance, haemodynamic disorder, metabolic disorders, necrosis and apoptosis of cardiomyocytes [1,2], accompanied by abnormal alterations of gene expression such as aberrant regulation of a number of ion channels [3] and β-adrenoceptors (β-AR) [4,5], and reduction in connexin43 [6,7], which can often lead to arrhythmias and acute and chronic heart failure.