In the 83 LSCC patients, a univariate analysis (Table 2) revealed that the DFS survival significantly correlated with expression of CD133 (P < 0.001) and KAI1/CD82 (P < 0.001), tumor location (P = 0.033), grade of tumor (P = 0.002), lymph node metastasis (P = 0.004), and pTNM stages (P < 0.001). The gene discussed is PROM1; the disease is metastatic malignant neoplasm in the lymph nodes.