Interestingly, also a number of oncogenes is up regulated by E2 (MERTK, RET and its ligand ARTN), and several (putative) tumor suppressor genes are down regulated by E2 (BLNK, LATS2, RPRM) that are not, or less, regulated by EGF (Additional file 8: Table S3). The gene discussed is ARTN; the disease is neoplasm.