EPHX1 and hepatocellular carcinoma: As shown in Figure 1C, endogenous mEH in Huh-7 hepatoma cells efficiently co-immunoprecipitated with full-length HBSP and HBSP1–47, but not HBSP48–111 or GAL4BD, indicating that the mEH-binding site of HBSP is located within the N-terminal half of the molecule (residues 1–47).