ITIH4 and HIV-1 infection: The recombinant Env gp120 protein derived from a CRF01_AE (A244) strain, A244-rgp120, and that derived from a subtype B (MN) strain, MN-rgp120, were used as immunogens in the RV144 clinical trial [52] and the majority of HIV-1 infection in the trial was caused by CRF01_AE viruses (91.7%) [53], which are the predominant CRF of HIV-1 prevalent in Thailand [26].