CEACAM5 and Pleural effusion: The diagnostic characteristics of single tumor marker in pleural effusion has been reported as follows: CEA (sensitivity 45.9%; specificity 97.0%), CA125 (sensitivity 48%; specificity 85%), CA15-3 (sensitivity 51%; specificity 96%), CA19-9 (sensitivity 25%; specificity 96%) and CYFRA21-1 (sensitivity 55%; specificity 91%) [6,7].