The glutamate-dopamine interaction modulates the release of dopamine in the nucleus accumbens through the pyramidal neuron-GABA interneuron network of the prefrontal cortex and corresponding outputs to the nucleus accumbens[33], suggesting that a disturbance in the glutamate-dopamine interaction may be involved in the pathophysiology of schizophrenia-like behavior in mGluR3 KO mice. The gene discussed is GRM3; the disease is schizophrenia.