PTEN and hepatocellular carcinoma: Of note, the PRC1 and PRC2/3/4 proteins can induce the repression of the PTEN transcription via binding to the PTEN promoter region in leukemic cells[26], while KIF20A is known to be controlled by the E2F–retinoblastoma protein–p16 pathway, and is linked to tumor aggressiveness in human hepatocellular carcinomas[27].