In a recent study Panebianco et al., in a population of 84 men (average PSA serum level 1.1 ng/mL in group A and 1.9 ng/mL in group B; mean size of the lesions 6 mm in group B and 13.3 mm in group B), found that a combined technique of 1H-MRSI and DCE-MRI at 3 Tesla magnet is a valid tool to detect locoregional PCa relapse and it is more accurate than Ch-PET/CT in the identification of small lesions in patients with low biochemical progression after RP (PSA serum values ranging from 0.2 to 2 ng/mL) [75]. Here, KLK3 is linked to posterior cortical atrophy.