In summary, in agreement with the literature data, Ch-PET/CT could play a role in managing patients with PCa, in particular during the restaging phase, thanks to its good Se with regard to systemic metastases and good detection rate in relationship with PSA serum value higher than 1 ng/mL, PSAdt lower than 6 months, and PSAvel higher than 2 ng/mL/year. Here, KLK3 is linked to posterior cortical atrophy.