Some authors have adopted a view based on recent research evidence suggesting that while CIS and SOCS1–3 are most often associated with regulation of cytokine receptor signalling through the JAK-STAT pathway, SOCS4–7 predominantly regulate growth factor receptor signalling via the control of receptor tyrosine kinases (RTKs) by target protein degradation and in the case of SOCS4 and SOCS5 also binding site competition [121, 129], while SOCS7 has been shown to directly bind signaling proteins to prevent their nuclear translocation and inhibiting their signal transmission [128]. This evidence concerns the gene SOCS4 and in situ carcinoma.