Hypermethylation and silencing of SOCS1 have been commonly reported in solid tumors, including 61% of cervical cancer samples [236] and 45% of oesophageal squamous cell carcinoma samples [237], as well as occasionally in Barrett's adenocarcinoma [238], with combined hypermethylation/gene loss observed in hepatocellular carcinoma [239]. This evidence concerns the gene SOCS1 and hepatocellular carcinoma.