SOCS3 hypermethylation was also seen in glioma [304] and also in prostatic cancer where aberrant methylation of SOCS3 was found in 39% of cases of prostate cancer in contrast to all benign (BPH) cases and normal control which showed a SOCS3 promoter nonmethylation [305]. The gene discussed is SOCS3; the disease is prostate carcinoma.