Persistent expression of SOCS1 and/or SOCS3 is observed in several haematological malignancies such as cutaneous T cell lymphoma (CTCL), chronic myeloid leukemia (CML), ALK+ anaplastic large cell lymphoma (ALCL), and some acute leukemia. The gene discussed is SOCS1; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.