CIS can interact with phosphorylated tyrosines in the cytoplasmic domains of several cytokine receptors such as GHR, EPOR, TPOR, IL-3 R, and IL-2 Rβ [31, 39, 46–48, 54, 150], and SOCS2 can interact with the activated IGF-I receptor [70]. The gene discussed is SOCS2; the disease is in situ carcinoma.