Loss of tight regulation of the stromal cell factor (SCF) receptor, C-KIT, can lead to the development of several human cancers [266, 267], and SOCS6 can bind directly to the juxtamembrane (JM) region of C-KIT following SCF stimulation and phosphorylation of murine C-KIT Y567 (human Y568) [126]. The gene discussed is KIT; the disease is cancer.