Interestingly, although it enhances reprogramming of normal somatic cells, resveratrol inhibits the stemness, epithelial-mesenchymal transition, and metabolic reprogramming of cancer stem cells to glycolysis through activation of p53, again highlighting the innate differences between the molecular circuitry of normal stem cells and cancer stem cells, a finding that can potentially be exploited for therapeutic purposes [239]. This evidence concerns the gene TP53 and cancer.