There was no significant difference in the frequency of classical monocytes (CD14++CD16−) among subjects with different degrees of periportal fibrosis (without fibrosis: without stimulus (WS) 56.3% (32.3%–73.9%), SEA 50.1% (32%–73.9%); incipient fibrosis: WS 45.4% (24.2%–71.6%), SEA 46.1% (22.3%–74.6%); moderate to severe fibrosis: WS 40.1% (19.2%–73.8%), SEA 46.5% (15.3%–75.6%). The gene discussed is CD14; the disease is fibrosis.