When they interrogated the metabolic functions of this mutant, they found that this mutant could still regulate metabolic target genes such as glutaminase-2 and 3, and TP53-induced glycolysis and apoptosis regulator (TIGAR) as well as genes involved in the regulation of reactive oxygen species indicating that metabolic regulation may be one function of p53 that is involved in tumor suppression [99]. This evidence concerns the gene TIGAR and neoplasm.