This study suggested that adjuvant regional radiotherapy in breast conservation therapy might elevate plasma IL-6 levels as a byproduct of the analysis of the indirect effect of radiotherapy on the indices of WMS-R through plasma IL-6 levels (Table 3), although the relation between radiotherapy for cancer patients and the levels of circulating proinflammatory cytokines after radiotherapy has been inconsistent in previous studies, that is, some studies showed elevated levels after irradiation 16,20, but others showed the opposite results 4,14,21,39. The gene discussed is IL6; the disease is cancer.