Taken together, the present study clearly demonstrates that GA exerts anti-apoptotic properties such as suppression of apoptosis and JNK/c-Jun signaling in 3NP-challenged striatal cells presumably through the expression of HSP 70, suggesting that GA may be a valuable therapeutic agent to increase the intracellular level of HSP 70, which plays a beneficial role in the pathogenesis of HD. Here, MAPK8 is linked to Huntington disease.