Firstly, since CD146 has also been identified as a novel molecule for inducing epithelial-mesenchymal transition (EMT) in tumor progression (Imbert et al., 2012; Liu et al., 2012; Zeng et al., 2012), not only does the absence or inhibition of CD146 function block tumor growth and angiogenesis; it is also likely to suppress tumor metastasis. Here, MCAM is linked to neoplasm.