A following study showed that VEGF mediates CD146 dimerization and downstream signaling in a NOX4-dependent manner (Zhuang et al., 2010), which aroused our interest on the association between CD146 and VEGF pathway and finally led to the important finding that CD146 is a co-receptor of VEGFR-2 in tumor angiogenesis. Here, NOX4 is linked to neoplasm.