ERCC2 and cancer: Several polymorphisms identified in genes of the BER pathway (XRCC1 and OGG1), NER pathway (ERCC1, XPC, and ERCC2/XPD), HR pathway (RAD51, BRCA1, XRCC3, and WRN), and NHEJ pathway (XRCC4 and MGMT) have been shown to be associated with risks for various cancers [7,10,12–15].