Table S6 and Figure S2c report functionally enriched terms including both up- and down-regulated genes, identifying GO terms such as negative regulation of extrinsic apoptotic signaling pathway (up-regulated: AGFG1, CFLAR and HTT; down-regulated: IGFBP1, RELA), B cell differentiation (up-regulated: ADAM17, MALT1, NCKAP1L, TP53; down-regulated: GPR183, INHA, RAG1) and pancreatic cancer (up-regulated: TGFA, TP53; down-regulated: BRAF, RELA, VEGFA). The gene discussed is GPR183; the disease is familial pancreatic carcinoma.