The down-regulated genes identified GO terms as melanoma, ERK1 and ERK2 cascade, myotube differentiation, enriched endochondrial ossification (BMP7, CTSV, IGF1R and VEGFA), negative regulation of bone resorption (calcium loss) (CD38 and VEGFA), negative regulation of FGFR signaling (BRAF and FGF20), renal carcinoma and other (Table S5 and Figure S2b). The gene discussed is MAPK3; the disease is melanoma.