In 2004, a meta-analysis [13] reported that compared with carriers of the apoE ε3/3 genotype, carriers of the apoE ε4 allele had a significant increased risk for CHD (OR, 1.30; 95% CI, 1.18 to 1.43), whereas the ε2 allele had no effect (OR, 0.93; 95% CI, 0.83 to 1.05). This evidence concerns the gene APOE and coronary artery disorder.