ACE and Hepatic fibrosis: The TGFβ-inhibitors perindopril, an angiotensin converting enzyme (ACE) inhibitor, valproic acid, a histone deacetylase inhibitor, rosmarinic acid and pirfenidone, antifibrotic compounds that inhibit the TGFβ expression, and tetrandrine, which up-regulates smad7, also demonstrated antifibrotic effects in vitro and in vivo in liver fibrosis [19]–[24].