In agreement with previous GWAS in AD [8], [13]–[16], [19] our meta-analysis detected strong genome-wide association signals in a 250 kb window of chromosome 19, centered in the coding/regulatory region of the TOMM40 gene, in close proximity to the APOE locus, and that also included significant signals in the PVRL2, APOC1, BCAM and BCL3 genes. This evidence concerns the gene NECTIN2 and Alzheimer disease.