APOE and Alzheimer disease: In agreement with previous GWAS in AD [8], [13]–[16], [19] our meta-analysis detected strong genome-wide association signals in a 250 kb window of chromosome 19, centered in the coding/regulatory region of the TOMM40 gene, in close proximity to the APOE locus, and that also included significant signals in the PVRL2, APOC1, BCAM and BCL3 genes.