In summary, we showed that leiomyoma express an elevated level of phosphorylated IKBKB at Ser-177/181 as compared to myometrium and using isolated MSMC and LSMC as an in vitro model provided further evidence for the regulatory function of miR-200c on IKBKB and caspase 3/7 activity. This evidence concerns the gene CASP3 and leiomyoma.