The observed significant down-regulation of myelin proteins like MBP, MOBP and PLP1, and a trend towards lower expression of CNP, MAG, and MOG in subacute CDV leukoencephalitis only is substantiated by immunohistological studies describing a loss of MBP and MAG in experimentally-induced CDV leukoencephalitis starting 16–21 days post infection and prior to the onset of perivascular inflammation [51]. Here, PLP1 is linked to infection.