A Leading Edge Analysis revealed that the three gene ontology terms “viral reproduction”, “viral infectious cycle”, and “viral reproductive process”, which were all positively correlated with demyelination, can be summarized into a cluster based on the shared genes chemokine (C-C motif) ligand 2 (CCL2), CD81 molecule (CD81), and topoisomerase (DNA) II alpha 170kDa (TOP2A) (Figure S2). This evidence concerns the gene TOP2A and Peripheral demyelination.