We found that Biostir-AD (266.53 ± 14.92 ng/mL, P < 0.01) increased the level of IgE compared with the control group (56.67 ± 14.91 ng/mL), whereas the IgE levels in mice administered with MAE (186.01 ± 8.07 ng/mL, P < 0.05) were lower than those in the Biostir group (Figure 6A). Here, IGHE is linked to Alzheimer disease.