Moreover, NQO1 has been found to be markedly up-regulated in active demyelinating MS lesions [13,14] Stavropoulou et al. [42], in a case–control association study involving 231 MS patients and 380 controls, reported an association between the rs1800566CT and TT genotypes and the risk of developing MS, and a higher incidence of rs1800566CT genotype in patients with primary progressive MS. The gene discussed is NQO1; the disease is myeloid sarcoma.