We employed the knowledge, attitudes, and behavior framework adapted by Cabana [19] to study reasons for PCP non-adherence to key components of the 2012 KDIGO CKD guidelines (i.e., assessing estimated glomerular filtration rate [eGFR] and albuminuria/proteinuria, definition of CKD, and use of angiotensin converting enzyme inhibitor [ACEi] or angiotensin II receptor blockers [ARBs] in overtly albuminuric/proteinuric patients) [18], focusing on non-diabetic CKD. The gene discussed is ACE; the disease is chronic kidney disease.