GATA2 and acute myeloid leukemia: GATA2 has recently been recognized as a MDS-AML predisposition gene, in addition to the previously reported RUNX1 and CEBPA. Since the first report of 4 families of heritable GATA2 mutations associated with familial AML-MDS by Hahn et al. in 2011, [10] there have been more than a dozen pedigrees reported in the literature (Table 2).