Carcinogenesis in CRC is a multistep event that includes a progressive accumulation of genetic alterations in multiple genes whose protein products are regulated by the UPS.3,4 Here, we report the expression pattern of a novel E2-conjugating enzyme, UBE2Q2, in colorectal carcinoma cell lines and colorectal primary tumors. This evidence concerns the gene UBE2Q2 and colorectal carcinoma.