Overexpression of UBE2Q2 in malignancies such as head and neck squamous cell carcinoma (HNSCC) and breast cancer as well as in most of the bone marrow samples from acute lymphoblastic leukemia patients has already been reported.26 Consistently, inactivation of UBE2Q2 is reported to cause cells to undergo prophase arrest and apoptosis in the M phase. Here, UBE2Q2 is linked to acute lymphoblastic leukemia.