UBE2Q2 and cancer: Accordingly, it has been suggested that UBE2Q2 might act as an oncogene to promote the development of aneuploidy or malignancy in the M phase.18 The results of one study however, revealed that overexpression of UBE2Q2 negatively affects cell proliferation and anchorage-independent cell growth, which implies that UBE2Q2 may be a potential tumor suppressor.27 If confirmed, one possible explanation for these controversies is that the upregulation of UBE2Q2 in cancer tissues may be due to an inactive form and/or a dominant-negative isoform of the protein.