In a TMA containing matched benign and PC samples from patients who underwent radical prostatectomy (median follow-up time 91 months, range 3–151), we found GABPα expression to be significantly higher in tumours (median H-score 153) compared with matched benign samples (median H-score 0) and in more aggressive, D’Amico high-risk Gleason score 8–10 PC (52) compared to Gleason score 6 PC (P < 0.05, Figure 1H–I, Supplementary Table S2). This evidence concerns the gene GABPA and pachyonychia congenita.