ETV1 and pachyonychia congenita: Genes associated with ERG- and ETV1-binding sites (GREAT closest feature analysis (45)) were significantly enriched for up-regulation in PC tissue and androgen-regulation in vitro (Figure 2F), in contrast to genes near GABPα-binding sites which were enriched for genes up-regulated in CRPC and showed greater enrichment for AR binding in CRPC tissue than AR binding in PC cell lines (Supplementary Table S4 and Figure 3G).