To define a core set of GABPα-regulated genes we selected genes showing both significant up-regulation in GABPα OE and down-regulation in GABPα KD, identifying 1825 genes in AD (LNCaP) cells and 1655 genes in CR (c4–2b) cells (with a 19% overlap, n = 316 genes, Supplementary Table S6). This evidence concerns the gene GABPA and Alzheimer disease.