Such differentially expressed genes in GABPα OE PC cells were associated with steroid biosynthesis, p53, Wnt, and MAPK signalling pathways, and were up-regulated in other cancers, including colorectal and renal cell (Figure 3F), providing further evidence for the role of GABPα in PC progression through these key oncogenic pathways and providing further cross-validation of the similarity with the role of ETV1 from previous studies (25,26). Here, GABPA is linked to pachyonychia congenita.