GABPA and pachyonychia congenita: Additionally, differentially expressed genes (either up- or down-regulated) in GABPα OE PC cells (both LNCaP and c4–2b cells, n = 3185) were able to segregate benign, primary and metastatic PC clinical samples, with the largest expression changes occurring in metastatic CRPC samples (65) (Figure 3E), highlighting the clinical importance GABPα targets in PC and CRPC.