Supporting this assumption, the observation of impaired autophagy in our model is similar to those obtained in some LMNA-related murine models: such as Lmna knockout mice (dilated cardiomyopathy and muscle dystrophy) and Zmpste24-deficient mice (extreme phenotype of premature aging) [50, 51]. This evidence concerns the gene ZMPSTE24 and dilated cardiomyopathy.