LMNA and premature aging syndrome: Interestingly, there is parallelism between the mesenchymal tissues affected in age-associated disorders and premature aging diseases arising from the accumulation of progerin or prelamin A. In fact, lipoatrophy, osteopenia, cardiomyopathy and atherosclerosis are frequently detected in aged individuals, as well as in patients with premature aging syndromes associated with LMNA gene, such as progeria or LMNA-linked lipodystrophy [57].