ZMPSTE24 and Hutchinson-Gilford progeria syndrome: These diseases, such as Hutchinson-Gilford Progeria syndrome (HGPS) or LMNA-linked lipodystrophy are caused by mutations in LMNA gene which encode several isoforms of A-type lamins, being among them Lamin A protein [3, 4], or in FACE1/Zmpste24 gene which encode a protease essential for the normal processing of Lamin A protein [5].